2006;97(1):111. OECD Guidelines for the Testing of Chemicals, Test no. https://doi.org/10.1016/S0031-9422(00)88630-6. J Agric Food Chem. Antioxidant and antimicrobial capacities of ethanolic extract of Pergularia daemia leaves: a possible substitute in diabetic management. International Journal of Phytomedicine and Phytotherapy, Clinical Phytoscience Ye M, Yan Y, Da G. Characterization of phenolic compounds in the Chinese herbal drug Tu-Si-Zi by liquid chromatography coupled to electrospray ionization mass spectrometry. Similarly, DPPH scavenging activity IC50 value was at 33.36 and 34.12mg/ml for extract and gallic acid respectively. Urine excreted for the next 5 h was collected and the total 5 h urine volume for each rat was compared with the volume of urine produced after the administration of normal saline. Similarly, root extract is used as an abortifacient, emetic and also used to treat against asthma, constipation and gonorrhoea. [59] reported that methanol dichloromethane (1:1v/v) extract of the whole plant extract inhibited the growth of the cancerous cells. Herbal medicines are directly synthesized from various parts of plants such as leaf, stembark, roots, barks, flowers, seeds, etc. P. daemia is a perennial climber, traditionally reported for the treatment in a variety of diseases. Asian J Pharm Clin Res. the contents by NLM or the National Institutes of Health. Many of these phytochemicals have beneficial effects on long term when consumed by humans and can be used effectively to treat various chronic diseases. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. Novel Strategy for Gallium-Substituted Hydroxyapatite/Pergularia daemia Rakhit S, Dhar MM, Anand N, Dhar ML. Shahidi F. Antioxidant factors in plant foods and selected oilseeds. Flavonoids and its glycosides, phytosterols, saponins, phenols, alkaloids, triterpenes, tannins and alkaloids are bioactive ingredient in hypoglycaemic activity in plants [63]. Usually it is found along the road side and that is why it is commonly called veli paruthi. PubMed The plant material was extracted by soxhlet with 50% alcohol and then concentrated. 1971;10(3):6679. 2008;17(S1):3802. Senthilkumar M, Gurumoorthi P, Janardhanan K. Antibacterial potential of some plants used by tribals in Maruthamalai hills, Tamil Nadu. In Ayurvedic system, herbal compositions were mostly prepared through polyherbal formulations. The herbal preparations are named as powers (Churna), decoction (Kwatha), resins (Guggul), oil (Taila) andinfusion (Phanta) etc., [7]. In some cases, the crude extracts of medicinal plants are used as an agent for the treatment of various diseases. The flavonoids from ethanol extract and ethanol fraction in P. daemia confirmed by HPTLC using quercetin-3-glucoside as a standard. Ellagitannins from Rubus berries for the control of gastric inflammation: In vitro and in vivo studies. Pharmacological datas obtained from scientific journals published from 2000 to 2020. Another study revealed that P. daemia extract has an important source to cure oral cancer disease. An important study on veliparuthi which really excited me was about its amazing use in treating poly cystic ovarian syndrome which affects many women now. The volume of urine excreted during 5 h for each animal in the group is expressed as the percent of the liquid (normal saline) administered. Asian J Tradit Med. Objective: The aim of this study is to evaluate the in vitro antioxidant potential and to determine the median lethal dose (LD 50) of crude ethyl acetate and methanol extracts of Pergularia daemia.The plant Pergularia daemia possess effective scavenging activity against 2, 2' azino bis (3 ethylbenzothiazoline 6 sulfonic acid (ABTS), nitric oxide and reducing power radicals at different . It includes monomeric flavanols, flavanones, anthocyanidins, flavones and flavanols (Fig. What are the Uses and Health Benefits of Pergularia Extensa? P. daemia is a perennial climber, traditionally reported for the treatment in a variety of diseases. The flavonoid biosynthetic pathway in Arabidopsis: structural and genetic diversity. Int J Pharm Pharm Sci. and medicinal plants could be a source for developing more effective drugs. Authors suggested that polyphenolic compounds principally triterpenoids play a vital role against growth of cancer cells. Borrelli F, Izzo AA. Aqil F, Ahmad I, Mehmood Z. Antioxidant and free radical scavenging properties of twelve traditionally used Indian medicinal plants. It is widely distributed in the tropical and sub tropicalregions of the world. PDF Phytochemical Studies on the Leaves of Pergularia Daemia Collected from 1996;7(2):6676. CAS Bhavina et al. 2018;10:103. bRofel, Shri G. M. Bilakhia College of Pharmacy, Vapi, India. Abascal K, Ganora L, Yarnell E. The effect of freeze-drying and its implications for botanical medicine: a review. Dhanasekaran D, Sivamani P, Panneerselvam A, Thajuddin A. Rajakumar, Selvamani S. biological control of tomato seedling damping off with Streptomyces sp. Phytochemistry. [citation needed] It has been used traditionally to treat a number of ailments. On comparison with other parts in plant, leaf and stem extract exhibited the vast flavonoids content. According to world health organization (WHO) report (2017), approximately 10.4 million cases of tuberculosis (TB) were reported in 2016 and one major possible cause of deaths. Wahi A, Ravi J, Hemalatha S, Singh P. Anti-diabetic activity of Daemia extensa R. Br J Natl Remedi. Research in medicinal plants has gained a renewed focus recently. Pharmacogn Mag. These characteristics strongly suggest these extracts are acting as loop diuretic. PDF Veliparuthi (Pergularia daemia (Forsk.) Chiov.) - As a phytomedicine: A Mini-Rev Med Chem. Ind J Res Pharma Biotech. The ethanolic extracts of P. daemia has significant (p<0.001) reduction in paw edema against carrageenan induced paw edema and cotton pellet granuloma methods in rats. In the present study, the ethanolic, pet ether, ethyl acetate and n-butanol extracts of P. daemia were screened for diuretic properties, to assess the medicinal potential of this plant. Terms and Conditions, Methodology With the support of electronic databases such as Science Direct, Google Scholar, Mendeley, Scirus and PubMed central. Article Bangalore: Interline Publishing Pvt. The flowers are in axillary pseudo umbells on long peduncles. PDF Antibacterial And Phytochemical Evaluation of Pergularia daemia - IJSRP To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Kreydiyyeh SI, Julnar V. Diuretic effect and mechanism of action of parsley. Front Pharmacol. CAS Devasagayam T, Tilak J, Boloor K, Sane KS, Ghaskadbi SS, Lele R. Free radicals and antioxidants in human health: current status and future prospects. Asian Pac J Trop Med. In: The science of flavonoids: Springer; 2006. p. 21338. 2011;10(4):7958. Compared with control rats there was decrease in LPO, malonaldehyde (MDA), and increase in serum protein antioxidant enzymes glutathione (GSH) in P. daemia extract treatment. Santosh MK, Sharanabasappa GK, Shaila D, Seetharam YN, Sanjeevarao I. Phytochemical studies on Bauhinia racemosa lam., Bauhinia purpurea Linn. Flavonoids were found to be the major and important phytochemicals obtained from extract of P. daemia aerial part during qualitative analysis. https://doi.org/10.1186/s40816-021-00295-z, DOI: https://doi.org/10.1186/s40816-021-00295-z. 2008;23(6):97684. Paracetamol also caused increase of serum liver enzymes such as bilirubin and cholesterol similar like CCl4. On the other hand, number of purified compounds from medicinal plants exhibited high antioxidant activity with least or no side effects. Google Scholar. [74] reported the ethanolic extract of P. daemia are better than the aqueous extract in exhibiting anthelmintic potential. 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Federal government websites often end in .gov or .mil. Saito K, Yonekura-Sakakibara K, Nakabayashi R, Higashi Y, Yamazaki M, Tohge T, et al. 2016;13(3):23945. Their findings also illustrated anti-inflammatory activity by membrane stabilization method in the ethanolic leaf (54.55%) and root (45.55%) extract at a concentration of 300g/ml and produced most significant stabilization compared to that of standard drug diclofenac sodium (72.73%) at 100g/ml concentration. 2014;6(10):198200. https://doi.org/10.1016/j.foodchem.2005.02.047. In addition, they mentioned small structural modification of triterpenoids as the ability to establish an oval drug against cancer [60]. The site is secure. Wahi AK, Ravi J, Hemalatha S, Singh PN. With the support of electronic databases such as Science Direct, Google Scholar, Mendeley, Scirus and PubMed central. [25]. The authors declare that they have no competing interests. Basic skeleton of flavonoids and its subgroups, Possible anti-inflammatory inhibition mechanism of flavonoids from P. daemia. On the other hand, isolation and identification of the bioactive compounds, extraction, purification and the mechanism of action of the purified compound is very important. Phytochemicals such as phenols, alkaloids, flavonoids, phytosterols, saponins, tannins and triterpenes found in the leaf extract might be responsible for the observed antioxidant activities [17, 50, 51]. IJPSR. All the extracts were not accompanied with reduction in urinary K+ level. Hel Helv Chim Act. J Nutr Biochem. (11). Full article: Pharmacognostic studies on Pergularia daemia roots Khorombi et al. https://doi.org/10.1016/j.plaphy.2013.02.001. At the highest concentration (160g/ml) of P. daemia methanolic extract, they confirmed maximum cytotoxic effect against oral KB cells. Sureshkumar and Mishra [68] reported that the ethanolic and aqueous extract of P. daemia possesses a significant (P<0.05) hepatoprotective effect against CCl4 induced hepatic rat model. Br J Nutr. Medicinal plants play a significant role in the progress of persuasive therapeutic agents. Traditional knowledge information collected by Indian taxonomical books, survey from local rural and tribal peoples. They evaluated the leaf extracts against round worm (Ascarislum bricoides), earthworm (Eudrillus eugeniae), and tapeworm (Taenia solium) taking 100mg/ml concentration, with albendazole as a reference drug. 2010;62(2):197206. PubMed Bhaskar VH, Balakrishnan N. Analgesic, anti-inflammatory and antipyretic activities of Pergularia daemia and Carissa carandas. https://doi.org/10.3923/ppj.2005.91.95. Pregnant women and women who are planning for pregnancy should not consume this herb as it has anti fertility properties. They were fasted 18 h prior to the test, with free access to water. If you are suffering from pcos, try this remedy for a week. Recent reports suggests that oxidative stress and its related factors cause an important problem to human health. Ethanolic extract and their steroidal fraction of P. daemia showed a potential anti-fertility activity. Artemisia asiatica extracts protect against ethanol-induced injury in gastric mucosa of rats. Sureshkumar SV, Mishra SH. The leaves are thin, opposite, membranous, 3-9 cm long, broadly ovate, orbicular or deeply cordate, acute or short-acuminate at apex, pubescent beneath. Leaves extract against anti-tuberculosis drugs induced liver injury in rats. 2018;16(9):1162. Phytother Res. The disposition of exogenous toxins and therapeutic agents are acting as a major part in the biochemical regulation of biomolecules such as fats, carbohydrates, amino acids and protein. J Gastroenterol Hepatol. Group I received vehicle (0.2 mL of 5% tween 80) and served as control group. In contrast, the diuresis induced by alcoholic, ethyl acetate and n-butanol extract of Pergularia daemia, was similar to that of furosemide and accompanied by marked increases in both urinary Na+ and K+ level. D.A.A, G.D and V.R.B: Writing- Reviewing and Editing. Recently, Sarkodie et al. Frawley D, Ranade S. Ayurveda, natures medicine. Piles Tumors Action of Pergularia Daemia Effective Analgesic Anthelmintic Krishna Government Degree College (Autonomous), Visakhapatnam, 530013, India, You can also search for this author in Flavonoids are the major phytocompound present in the P. daemia extracts and the concentration ranged from 72.5490.449 to 400.1960.339mg/ml. Particularly ethyl acetate extract (300mg/kg b.w.) 2010;1(4):3715. Food Chem. Wistar albino rats (180-250 g) and Swiss albino mice of either sex were acclimatized for 7 days under standard husbandry conditions, i.e. These drug formulations are either directly derived from aerial part of the plant or derived from other specific parts like leaf, root, stem, bark, flower and seed. Acute toxicity studies showed that the alcoholic extracts did not cause any mortality up to 2000 mg/Kg and were considered as safe (17). Extracts (400mg/kg) exhibited an inhibition percentage of 63.01 and the standard drug treated group showed 78.73%. Subhose V, Srinivas P, Narayana A. Flavonoids are known to be effective phytocompounds in treating the anti-rheumatic condition in animal models [13]. Mirunalini S, Karthishwaran K, Vaithiyanathan V. Antiproliferative potential of Pergularia daemia (Forsk.) This plant has been reported to have anti-fertility (4), antidiabetic (5), wound healing (6), antibacterial (7), anti-inflammatory (8) and hepatoprotective activity (9).The plant extract is useful in uterine and menstrual disorder and in facilitating parturition. Other extracts such as n-butanol, benzene and chloroform showed 16.83%, 13.96% and 15.08% respectively at the same concentration [54]. ), ethanolic extract (400 mg/Kg), pet ether extract (400 mg/Kg), ethyl acetate extract (400 mg/Kg) and n-butanol extract (400 mg/Kg) respectively. 3b). https://doi.org/10.1016/j.chroma.2008.06.002. https://doi.org/10.1002/1099-1573(200012)14:8<581::AID-PTR776>3.0.CO;2-S. D.A.A. On the other hand, the leaves of this plant are also used as an effective medicine for anemia, leprosy, arthritis, hemorrhoids, amenorrhea, dysmenorrheal, infantile diarrhea, body pain, asthma, bronchitis and whooping cough [10]. J Pharmacogn Phytochem. Sureshkumar S, Mishra S. Hepatoprotective effect of Pergularia daemia (Forsk.) Antifertility activity of the alkaloidal fraction of Pergularia daemia. PDF Pergularia Daemia- As an Excellent Phytomedicine In both the cases, assays were compared with standard drug diclofenac sodium at the concentration of 100g/ml. In vitro anti-inflammatory and anti arthritic activity of Pergularia daemia leaves and roots. https://doi.org/10.3109/13880208509069006. A single medicinal herb contains one or more phytochemical components that are synergistically active as a pharmacological agent. [55] investigated carrageenan induced paw edema in rats using chloroform and petroleum ether extract of whole plant. P. daemia contains these phytochemicals which might be the responsible for anti-ulcer activity. (Trellis-vine): a review. 2012;25(4):46674. https://doi.org/10.1007/s12291-014-0446-0. PubMed Turk J Biol. 2004;42(4):60917. CAS Traditionally the plant P.daemia was used as anthelmintic, laxative, antipyretic and expectorant, and was also used to treat infantile diarrhoea and malarial intermittent fevers and possesses stomachic, laxative and diuretic properties, useful in cough, biliousness and sore eyes (1-3). Google Scholar. Meena AK, Bansal P, Kumar S. Plants-herbal wealth as a potential source of ayurvedic drugs. You can easily find this plant in most of the villages in India and its found in most of the Asian countries and in Africa. Your US state privacy rights, Phytochemical constituents such as polyphenolic compounds, tannins, terpenoids are reported to be effective against various disorders [8]. And Hardwickia binate Roxb. Secondary metabolites such as alkaloids, flavonoid and steroids might be the possible candidates responsible for the diuretic activity of P. daemia. The important sub classes of flavonoids are flavanols, flavanones, isoflavones, flavones, and anthocyanidins [18, 42, 43]. Pergularia Daemia Herb Uses, Benefits, Cures, Side Effects, Nutrients room temperature 35 1C, relative humidity 45-55% and light/dark cycle 12/12 h. The experimental protocols were approved by the Institutional Animal Ethical Committee (IAEC) of CPCSEA (Committee for the Purpose of Control and Supervision of Experiments on Animals). In present review, we focused on the present status of phytochemical and pharmacological activities P. daemia. Pergularia daemia is used in Cameroon to treat pain, fever, arthritis, infections, and temporal lobe epilepsy. aMaliba Pharmacy College, Gopal Vidyanagar, Tarsadi, India. [63] revealed that that P. daemia extract has anti-hyperglycaemic activity against STZ-induced rat models. This chronic inflammation linked with serious inflammatory diseases including arthritis, cancer, neurological, metabolic and cardiovascular diseases [52, 53]. Mass spectrometry (MS) is mainly used for both quantitative and qualitative analysis of biomolecules. https://doi.org/10.1016/j.etp.2009.05.008. Biofactors. PubMed In conclusion, the extract might be able to act as loop diuretic and for understanding its mechanism of action more experiments is required. Indian J Chem B. Park SW, Oh TY, Kim YS, Sim H, Park SJ, Jang EJ, et al. Ltd.; 2000. Therefore, plants are recognised as major resource for phytocompounds with profound biological activities [9]. Seshadri T, Vydeeswaran S. Chemical examination of Luffa echinata. Further the urine was slightly acidified (Table 3). J Sci Ind Res (India). 3. 5). 2014;5(1):448. ABSTRACT:The plantPergularia daemia has been traditionally used as anthelmintic, laxative, antipyretic expectorant andalso used to treat infantile diarrhea and malarial intermittent fevers. Subramanya S, Venkataraman B, Meeran M, Goyal S, Patil C, Ojha S. Therapeutic potential of plants and plant derived phytochemicals against acetaminophen induced liver injury. 2007;3(11):18791. Secondary metabolites such as flavonoids, tannins and triterpenes has been extensively reported for anti-ulcerogenic activity [77]. Administration of ATDs significantly decreased the level of glucose and albumin. These findings suggest that among the mentioned extracts, ethanolic has the maximum diuretic activity followed by n-butanol extract. https://doi.org/10.1002/ptr.1651. The proportion of plant usage in the different Indian systems of medicine is Ayurveda (2000), Siddha (1300), Unani (1000), Homeopathy (800), Modern (200) and Folk (4500) [1]. However, medicinal plants like P. daemia have curative effects with least side effects [13]. Highly reactive trichloro free radical was generated by CCl4, which attacks polyunsaturated fatty acids. Click Here. Bhaskar V, Balakrishnan N. Veliparuthi (Pergularia daemia (Forsk.) Sci World J. Phaniendra A, Jestadi DB, Periyasamy L. Free radicals: properties, sources, targets, and their implication in various diseases. 2004;1054(12):95111. PubMed 2005;4(2):915. 2014;7(5):8995. It can also applied for toothache and for external ear infections. The https:// ensures that you are connecting to the Overproduction of ROS/RNS lead to failure in the defence mechanism by release of oxidant substances. Kumar KR, Lohmann K, Klein C. Genetics of Parkinson disease and other movement disorders. Liver is an incredible organ and is fundamental chemical laboratory of our body which plays a crucial role in the metabolism and detoxification of various chemicals and toxins enter into the body. Patwardhan B, Warude D, Pushpangadan P, Bhatt N. Ayurveda and traditional Chinese medicine: a comparative overview. Clin Phytosci 7, 60 (2021). Diuretic activity of alcoholic extract was found to be highest 0.93 followed by 0.79 of n-butanol and 0.76 of ethyl acetate extract (Table 2). 1968;7(9):17034. Medicinal and aromatic plants are rich in bioactive secondary metabolites like phenolic acids, flavonoids, alkaloids, glycosides, phytosterols, terpenoids, tannins. Hepatoprotective activity of extracts from Pergularia daemia (Forsk) against carbon tetrachloride-induced toxicity in rats. * p < 0.001. 2001;33(4):2606. Indian J Clin Biochem. Whereas, the clinical studies and its mechanisms of action are not clear. Effect of different extracts of Pergularia daemia on electrolyte excretion and pH in the rat, Each value represents the mean + SEM. They confirmed by membrane stabilization assay, and the highest % activity was observed in leaf (54.55%) than root (45.55%). Trellis-vine, Hariknot plant and Pergularia. Further studies are required to identify other bioactive compounds of P. daemia along with their specific mechanism in disease management. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Steroidal fraction of 200mg/kg showed significant activity against female mice at the stage of pre-implantation. A survey of the plants of Bhagalpur and Santhal pargana for saponin, flavonoids and alkaloids. Medicinal plants are known to be a natural source of phytochemicals and bioactive compounds. The results show that alcoholic extract, ethyl acetate extract and n-butanol extract of Pergularia daemia (Table 3) affects urinary electrolyte. NE Br. Amelioratory effect of flavonoids rich Pergularia daemia extract against CFA induced arthritic rats. 2015;30(1):1126. MS is a well known and successful technique for mass determination and structural elucidation of biomolecules. Sarkodie JA, Squire SA, Bekoe EO, Domozoro CYF, Kretchy IA, Ahiagbe MKJ, et al. The ROS plays a vital role in liver damage. Herbal medicine is a part of alternative treatment method and it includes the use of different medicinal plants and their extracts. CAS 2016;13(1):2431. This percentage gives a measure of urinary excretion independent of the animal weight. Chiov. In this context more emphasis has to be laid on studies that discuss on the secondary metabolite activities and molecular mechanisms that work against various chronic diseases. [20] study revealed that P. daemia methanolic extract exhibited an anti-proliferative effect against oral keratin-forming tumor cell line HeLa (KB) cells. Leaf extract showed an effective cytotoxic activity against ovarian cancer cell lines (PA-1 and OAW-42) and IC50 value of cell lines recorded 30 and 120mg/ml, respectively. Nowadays many people prefer these natural medicines additional for their advantage of being cost-effective and safe. 2013;8(8):e71762. Correspondence to Also ethanolic extract effectively inhibited the formation of peroxides and hydrogen peroxides. Hence, different plants have been studied using recent scientific approaches to classify various biological compounds of these medicinal plants. Phytocompounds can be extracted from fresh or dried plant samples. J Assoc Physicians India. Diuretic action of alcoholic extract was found to be 2.04units, which was almost similar to standard furosemide (2.19units). Natural flavonoids and cardenolides are the important bioactive compounds reported in P. daemia extracts. The data were expressed as mean SEM. Cookies policy. MS is a well known and successful technique for mass determination and structural elucidation of biomolecules [27]. It was also proven of its effectiveness in treating toothache and also in a study done on rats showed significant antihyperglycemic activity (diabetic control). Google Scholar. Some of the herbal drugs are derived from plant excretory products such as latex, resins and gum [3]. Shad AA, Ahmad S, Ullah R, AbdEl-Salam NM, Fouad H, Ur Rehman N, et al. In recent years, P. daemia phytoconstituents set as a key role in natural drug development as it harbours many in vitro and in vivo pharmacological activities such as anti-inflammatory, anti-cancer, anti-fertility, anti-arthritic andantimicrobial etc.. P. daemia was the less studied plant compared to other medicinal plants. These flavonoids have the potential inhibit the pro inflammatory mediators and other inflammatory agents (Fig. Whereas, other arthritis indicator biomarkers including white blood cells (WBC) count (8.910.38 thousands/mm3), rheumatoid factor (RF) (17.940.45IU/ml), erythrocyte sedimentation rate (ESR) (7.910.12mm/h) and C-reactive protein (CRP) (22.560.26mg/l) levels were significantly decreased when compared arthritic induced rat group [56]. extract in vitro and in vivo experiments on hamster buccal pouch carcinogenesis. Lipschitzs test used for this study and furosemide used as a standard drug. Liver injury or damage is a well known disease which can be caused by excessive production of ROS that lead to the hepatic cells and tissue damage. Importantly, anti-inflammatory activities of phytocompounds have been described in earlier reports and some of them are in preclinical trials at present [16]. Vaithiyanathan V, Mirunalini S. Assessment of anticancer activity: A comparison of dose response effect of ethyl acetate and methanolic extracts of Pergularia daemia (Forsk). Phytochemicalsreported inP. daemia. 4). Secondary metabolites extracted from the medicinal and aromatic plant extract are mostly responsible for the therapeutic and pharmacological potential of the particular plants [13]. https://doi.org/10.1371/journal.pone.0071762. statement and 1954;18B:4226. Bioactive phytocompounds are very limited source as these are not feasible to obtain from all plant types. PubMed Central Springer Nature. While, 70% ethanolic extract of P. daemia leaf revealed significant DPPH free radical scavenging activity on par with commercial standards of ascorbic acid and BHT.